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Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol
Yoshikazu Kitano1, Chika Akima, Erina Yoshimura
1Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo, Japan. kitayo@cc.tuat.ac.jp
Abstract:
Twenty novel simple alkyl isocyanides derived from citronellol were synthesized and evaluated for their antifouling activity and toxicity against cypris larvae of the barnacle, Balanus amphitrite. The anti-barnacle activity of the synthesized isocyanides was in the EC(50) range of 0.08-1.49 μg ml(-1). Simple isocyanides containing a benzoate and chloro group showed the most potent anti-barnacle activity. In addition, none of the synthesized compounds showed significant toxicity and LC(50) values were <10 μg ml(-1). The LC(50)/EC(50) ratios of almost all of the synthesized compounds were >10(2). The results indicate that these simple isocyanides are promising low-toxicity antifouling agents.
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