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Published on: August 14, 2019
Three new flavonoids from the active extract of Fallopia convolvulus
Chao-Feng Zhang1, Jing Chen, Li-Qing Zhao
1Key Laboratory of Modern Chinese Medicines, Ministry of Education, Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China. njchaofeng@126.com
Journal of Asian Natural Products Research
|February 1, 2011
Summary
Fallopia convolvulus extracts were tested for their ability to inhibit nitric oxide production in activated macrophages. The study identified new and known flavonoid compounds with potential anti-inflammatory properties.
Area of Science:
- Phytochemistry
- Immunology
- Pharmacology
Background:
- Fallopia convolvulus is a plant with a history of traditional medicinal use.
- Nitric oxide (NO) production in macrophages is a key indicator of inflammation.
Purpose of the Study:
- To investigate the anti-inflammatory potential of Fallopia convolvulus extracts.
- To isolate and identify bioactive compounds from the plant.
Main Methods:
- Solvent extraction of Fallopia convolvulus using ethanol, petroleum ether, ethyl acetate (EtOAC), n-butanol, and water.
- Evaluation of inhibitory effects on nitric oxide production in lipopolysaccharide-activated macrophages.
- Isolation and structural elucidation of compounds using spectroscopic analysis.
Main Results:
- The ethyl acetate (EtOAC) extract exhibited significant inhibitory effects on nitric oxide production.
- Three new flavonoids (falloconvolin A, falloconvolin B, and quercetin-3-O-(2-E-sinapoxyl)-glucopyranoside) were isolated.
- Seventeen known phenolic compounds were also identified.
Conclusions:
- Fallopia convolvulus contains bioactive flavonoids with potential anti-inflammatory properties.
- The ethyl acetate (EtOAC) extract is a promising source for developing anti-inflammatory agents.
