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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
Incidence of intraventricular hemorrhage and post hemorrhagic hydrocephalus in preterm infants
Negar Sajjadian1, Hossein Fakhrai, Ramin Jahadi
1Department of Neonatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. NSajjadian@ yahoo.com
Insights
Germinal matrix-intraventricular hemorrhage (IVH) affects premature infants, often leading to hydrocephalus. Early brain sonography can detect IVH and hydrocephalus, aiding in management and potentially preventing complications.
Area of Science:
- Neonatal Neurology
- Pediatric Radiology
- Critical Care Medicine
Background:
- Germinal matrix-intraventricular hemorrhage (IVH) is a common intracranial hemorrhage in premature infants.
- IVH can lead to serious complications, including hydrocephalus.
- Brain sonography is the primary diagnostic tool for IVH and hydrocephalus.
Purpose of the Study:
- To determine the incidence of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus in premature neonates.
- To evaluate the effectiveness of brain sonography in detecting these conditions.
- To explore the relationship between IVH severity and hydrocephalus development.
Main Methods:
- Brain sonography was performed on premature neonates (birth weight ≤1500 g, gestational age ≤37 weeks) within the first week of life.
- Serial brain sonography was conducted weekly for neonates with confirmed IVH to monitor for hydrocephalus.
- The study population included 57 neonates admitted to Mofid Hospital NICU over one year.
Main Results:
- Intraventricular-germinal matrix hemorrhage (IVH) was detected in 64.4% of the neonates studied.
- Hydrocephalus was identified in 20% of patients with IVH.
- A direct correlation was observed between the severity of IVH and the incidence of hydrocephalus.
Conclusions:
- The incidence of IVH in this study population was higher compared to other regions.
- Controlling risk factors for IVH may help in preventing post-hemorrhagic hydrocephalus.
- Early detection and monitoring using brain sonography are crucial for managing IVH and hydrocephalus in premature infants.
Abstract:
Germinal matrix-intraventricular hemorrhage (IVH) is the most common variety of neonatal intracranial hemorrhage and is characteristics of the premature infant. The importance of the lesion relates not only to its high incidence but to their attendant complications (IC: hydrocephalus). Brain sonography is the procedure of choice in diagnosis of germinal matrix- intraventricular hemorrhage and hydrocephalus. In this study we have used brain sonography for detection of intraventricular hemorrhage and post hemorrhagic hydrocephalus and their incidences. The studied population was consisted of premature neonate (birth weight equal or less than 1500 g and gestational age equal or less than 37 weeks) who admitted in Mofid Hospital NICU (Tehran, Iran) during a one year period. For all neonate (including criteria) brain sonography in first week of life was done and in presence of IVH, serial Brain sonography was done weekly for detection of hydrocephalus. A total of 57 neonate entered the study. Intraventricular-germinal matrix hemorrhage was seen in 64.4% (35 patients). Forty percent of patients with intraventricular-germinal matrix hemorrhage had grade I, 11% grade II, 25.7% grade III, 2.8% grade VI. Hydrocephalus was detected in 20 percent of patients who had intraventricular-germinal matrix hemorrhage. That incidence of IVH in our study in comparison with other area and situation is higher. Hydrocephaly had direct relation with severity of IVH. This shows that with control of risk factor of IVH, we can control Post hemorrhagic hydrocephalus.
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