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Renal acidification in sickle cell trait.

J R Oster, S M Lee, L E Lespier

    Archives of Internal Medicine
    |January 1, 1976
    PubMed
    Summary

    Adults with sickle cell trait show diminished renal concentrating ability but normal kidney function and blood acid-base balance. This study on sickle cell trait found no adverse effects from acid loading.

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    Area of Science:

    • Nephrology
    • Hematology
    • Physiology

    Background:

    • Sickle cell trait (SCT) is a common inherited blood disorder.
    • Understanding the renal function in SCT is crucial for managing potential complications.

    Purpose of the Study:

    • To investigate the renal concentrating ability and acidification in individuals with sickle cell trait.
    • To assess the impact of acid loading on renal hemodynamics and red blood cell 2,3-diphosphoglycerate levels in SCT.

    Main Methods:

    • Nine subjects with sickle cell trait and nine controls underwent a six-hour ammonium chloride acid loading test.
    • Maximal urine osmolality, renal hemodynamics, and acid excretion were measured.
    • Arterial pH, Pco2, [HCO3], and red blood cell 2,3-diphosphoglycerate levels were monitored.

    Main Results:

    • Subjects with sickle cell trait exhibited lower maximal urine osmolality compared to controls.
    • Renal acidification and hemodynamics were comparable between the two groups.
    • Ammonium chloride acidosis did not induce sickling or adverse effects in SCT subjects.

    Conclusions:

    • Adults with sickle cell trait have diminished renal concentrating ability.
    • Renal acidification and hemodynamics remain normal in individuals with sickle cell trait.
    • Acid loading is safe and does not precipitate adverse events in sickle cell trait.

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