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Interaction of glycyrol with calcineurin A studied by spectroscopic methods and docking

Liqin Peng1, Yao Qi, Hezhen Wu

  • 1Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing, China.

IUBMB Life
|February 1, 2011
PubMed

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Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...