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Updated: Jun 4, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Nanoengineered surfaces enhance drug loading and adhesion
Kathleen E Fischer1, Aishwarya Jayagopal, Ganesh Nagaraj
1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, United States.
Abstract:
To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.
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