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Related Experiment Video

Updated: Jun 4, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Nanoengineered surfaces enhance drug loading and adhesion.

Kathleen E Fischer¹, Aishwarya Jayagopal, Ganesh Nagaraj

¹Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, United States.

|February 2, 2011

Summary

Silicon nanowires enhance the delivery of therapeutic macromolecules to gastrointestinal cells. These nanowires increase loading capacity and maintain particle adhesion, overcoming mucosal barriers for improved drug delivery.

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Area of Science:

Biomaterials science
Drug delivery systems
Nanotechnology

Background:

Macromolecule delivery to gastrointestinal cells faces significant mucosal barriers.
Previous work demonstrated silicon nanowires penetrate mucus and adhere to cells under shear.
Effective delivery requires macromolecules in close proximity to target cells.

Purpose of the Study:

To characterize reservoirs for macromolecule loading within silicon nanowire structures.
To evaluate the loading capacity of these nanowire-based reservoirs.
To assess the adhesion of loaded macromolecules under physiological shear forces.

Main Methods:

Nanowire structures were fabricated and characterized for interstitial space.
Macromolecules were loaded into the interstitial spaces between silicon nanowires.
Adhesion of loaded nanowire-macromolecule constructs was tested under high shear conditions.

Main Results:

Silicon nanowires create reservoirs that significantly increase macromolecule loading capacity.
The nanowire structures maintain strong adhesion of loaded macromolecules even under high shear stress.
This approach facilitates enhanced proximity of therapeutic agents to target cells.

Conclusions:

Silicon nanowires serve as effective reservoirs for therapeutic macromolecules.
Nanowire-based delivery systems improve loading capacity and adhesion for gastrointestinal applications.
This technology offers a promising strategy to overcome mucosal barriers for enhanced drug delivery.