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Updated: Jun 4, 2026

Laser-induced Forward Transfer of Ag Nanopaste

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Published on: March 31, 2016

Metallic foil-assisted laser cell printing.

Yafu Lin¹, Yong Huang, Douglas B Chrisey

¹Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, USA.

Journal of Biomechanical Engineering

|February 2, 2011

Summary

Metallic foil-assisted laser-induced forward transfer (LIFT) improves cell printing resolution and viability. This novel method enhances biological construct fabrication by minimizing cell damage and contamination.

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Area of Science:

Biotechnology
Materials Science
Cell Biology

Background:

Laser direct-write technologies, including modified laser-induced forward transfer (LIFT), show promise for biological construct fabrication.
However, cell injury and death during modified LIFT processes remain significant challenges for its widespread application.

Purpose of the Study:

To introduce a metallic foil-assisted LIFT technique using a four-layer structure to enhance droplet size control and improve cell viability.
To evaluate the effectiveness of this method for direct writing of human colon cancer cells (HT-29).

Main Methods:

A four-layer structure was designed, comprising a quartz disk, sacrificial/adhesive layer, metallic foil, and cell suspension layer.
Droplet formation was achieved through bubble formation-induced stress waves.

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Human colon cancer cells (HT-29) were directly written using the metallic foil-assisted LIFT approach.

Main Results:

The metallic foil-assisted LIFT method demonstrated superior printing resolution compared to conventional modified LIFT techniques like matrix-assisted pulsed-laser evaporation direct-write.
High post-transfer cell viability was achieved with the proposed approach.
The use of a metallic foil minimized potential contamination from laser energy absorbing materials.

Conclusions:

Metallic foil-assisted LIFT is an effective cell direct-write technology for biological construct fabrication.
This method offers improved printing resolution and significantly higher cell viability.
The technique effectively reduces contamination risks associated with laser direct-write processes.