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Method for optical coherence elastography of the cornea.

Matthew R Ford¹, William J Dupps, Andrew M Rollins

¹Case Western Reserve University, Department of Biomedical Engineering, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

Journal of Biomedical Optics

|February 2, 2011

Summary

This study introduces a new corneal elastography technique using optical coherence tomography (OCT) to measure corneal material properties. This non-destructive method may aid in early diagnosis of corneal ectatic diseases like keratoconus.

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Area of Science:

Ophthalmology
Biomedical Engineering
Materials Science

Background:

Corneal material properties significantly influence corneal shape and refractive power.
Corneal ectatic diseases, such as keratoconus, involve material property abnormalities, leading to progressive thinning and distortion.
These conditions are a primary reason for corneal transplantation.

Purpose of the Study:

To describe a novel corneal elastography technique utilizing optical coherence tomography (OCT).
To enable non-destructive estimation of local and directional corneal material properties.
To provide a framework for in vivo quantification of corneal elastic and viscoelastic resistance for early disease diagnosis.

Main Methods:

Developed a corneal elastography technique based on OCT imaging.

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Employed a 2-D cross-correlation algorithm to track displacement of intracorneal optical features.

Conducted phantom experiments to assess the impact of image noise and displacement on tracking accuracy, and tissue experiments to map intracorneal displacement.

Main Results:

Demonstrated accuracy within micromechanical translation stage tolerance in phantom experiments.
Successfully produced 2-D maps of heterogeneous intracorneal displacement using OCT in tissue experiments.
Validated the ability to assess tissue under in situ mechanical conditions with physiologic stress levels.

Conclusions:

The described OCT-based corneal elastography is a non-destructive optical method for assessing corneal mechanical properties.
The technique allows for in vivo quantification of 3-D corneal elastic and viscoelastic resistance.
This approach holds potential for the early diagnosis of corneal ectatic diseases.