Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Buccal mucosal graft after posterior lamellar resection for eyelid sebaceous carcinoma.

Orbit (Amsterdam, Netherlands)·2026

Same author

Periorbital Necrotizing Sweet Syndrome: A Case Report and Literature Review.

Ophthalmic plastic and reconstructive surgery·2025

Same author

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review.

Ophthalmic plastic and reconstructive surgery·2023

Same author

Occam versus Hickam.

Survey of ophthalmology·2022

Same author

Suspected orbital myositis associated with COVID-19.

Orbit (Amsterdam, Netherlands)·2021

Same author

Pediatric Eye Emergency Department Visits: Retrospective Review and Evaluation.

Journal of pediatric ophthalmology and strabismus·2021

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Orbital sarcoidosis treated with hydroxychloroquine.

Michael P Rabinowitz¹, Ann P Murchison

¹Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA.

Orbit (Amsterdam, Netherlands)

|February 2, 2011

Summary

Orbital sarcoidosis involving extraocular muscles and orbital fat can be effectively treated with hydroxychloroquine when corticosteroids fail. This anti-malarial therapy showed no side effects or recurrence in the reported case.

Area of Science:

Ophthalmology
Rheumatology
Immunology

Background:

Orbital sarcoidosis is a rare granulomatous disease affecting the orbit.
It can involve extraocular muscles and orbital fat, leading to significant morbidity.
Standard treatment often involves corticosteroids, but resistance can occur.

Observation:

A patient presented with orbital sarcoidosis refractory to oral corticosteroid therapy.
The sarcoidosis involved both extraocular muscles and orbital fat.

Findings:

Successful treatment was achieved using oral hydroxychloroquine.
The patient experienced no adverse effects or disease relapse during follow-up.
This represents a novel therapeutic approach for refractory orbital sarcoidosis.

Related Experiment Videos

Last Updated: Jun 4, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Implications:

Hydroxychloroquine may be a viable alternative treatment for corticosteroid-resistant orbital sarcoidosis.
Anti-malarial therapy could offer a new strategy for managing isolated orbital sarcoidosis.
Further research is warranted to explore the efficacy and safety of hydroxychloroquine in larger cohorts.