Related Experiment Videos
No effect of doxapram during enflurane-nitrous oxide anesthesia
C J Jones1, B Dworacek, J Rupreht
1A. H. Robins Co. Ltd., Crawley, West Sussex, UK.
Acta Anaesthesiologica Belgica
|January 1, 1990
Summary
Doxapram did not significantly affect ventilation in patients receiving enflurane and nitrous oxide anesthesia. Surgical stimulation and nitrous oxide may have counteracted enflurane
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Enflurane and nitrous oxide are common anesthetic agents.
- Ventilatory depression is a known side effect of anesthetics.
- Doxapram is a respiratory stimulant.
Purpose of the Study:
- To investigate the effect of doxapram on ventilation during enflurane and nitrous oxide anesthesia.
- To assess the impact of surgical stimulation and nitrous oxide on anesthetic-induced respiratory depression.
Main Methods:
- Fifty spontaneously breathing patients undergoing surgical anesthesia with enflurane and nitrous oxide received doxapram.
- A control group of similar patients was used for comparison.
Main Results:
- No significant depression of ventilation was observed in the control group.
- Doxapram administration did not lead to a reduction in end-tidal CO2 concentrations.
- The expected ventilatory stimulant effect of doxapram appeared attenuated.
Conclusions:
- Surgical stimulation and nitrous oxide may mitigate the ventilatory depressant effects of enflurane.
- Enflurane's action on peripheral chemoreceptors might attenuate the efficacy of doxapram.