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Related Experiment Video

Updated: Jun 4, 2026

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C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis.

Briony H A Jack1, Richard C Pearson, Merlin Crossley

  • 1School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

The International Journal of Biochemistry & Cell Biology
|February 2, 2011
PubMed
Summary

C-terminal binding protein (CtBP) is a key regulator in adipocyte development, influencing gene expression changes. This protein links cellular metabolism to transcriptional control, impacting both white and brown fat cell formation.

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Area of Science:

  • Molecular biology
  • Cell biology
  • Metabolic research

Background:

  • Adipocyte differentiation requires precise gene expression control.
  • Transcription factors and coregulators manage these expression changes.
  • C-terminal binding protein (CtBP) is identified as a crucial transcriptional coregulator in adipose tissue.

Purpose of the Study:

  • To investigate the role of CtBP in adipocyte development.
  • To understand how CtBP regulates gene expression in white and brown adipocytes.
  • To explore CtBP's connection to cellular metabolic state via NAD(+)/NADH binding.

Main Methods:

  • Analysis of gene expression during adipocyte differentiation.
  • Identification of CtBP interacting partners.
  • Biochemical assays to study CtBP's NAD(+)/NADH binding.

Main Results:

  • CtBP acts as a key coregulator in the differentiation of both white and brown adipocytes.
  • CtBP functions with various partner proteins to control adipogenesis.
  • CtBP's NAD(+)/NADH binding suggests a mechanism linking nutrient status to transcriptional regulation.

Conclusions:

  • CtBP is essential for adipocyte maturation.
  • CtBP integrates metabolic signals into gene expression programs during adipogenesis.
  • Targeting CtBP may offer new avenues for metabolic disease therapies.