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IL-2: a two-faced master regulator of autoimmunity

Rahul Sharma1, Shu Man Fu, Shyr-Te Ju

  • 1Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, VA, USA.

Journal of Autoimmunity
|February 2, 2011
PubMed
Summary

Interleukin-2 (IL-2) uniquely regulates autoimmunity. While essential for preventing autoimmune disease by maintaining regulatory T-cells (Treg), IL-2 also promotes autoimmune responses, highlighting its dual role.

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