[Sapylin immunotherapy in oral squamous cancer]

A streptococcal preparation, Sapylin, was employed for 27 cases of oral squamous cancer without treatment that was injected into normal submucosa or sub-skin around the tumor. The recent clinical efficacy is as follows: 3 cases specially effective, 10 cases marked effective, 6 cases effective and 8 cases not effective. Effective percent 70%. A delayed SK-SD skin reaction were found to enhance, but NK activity and T-Rosette were not. A middle grade fever was present as a side effect of this preparation. The result suggested Sapylin that may be a useful to biological response modifier (BRM) agent for oral squamous cancer.