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Activity of ACHN-490 tested alone and in combination with other agents against Pseudomonas aeruginosa
Glenn A Pankuch1, Gengrong Lin, Aya Kubo
1Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Abstract:
ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was synergistic against most isolates at 24 h, and antagonism was not observed. Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-tazobactam yielded synergies in ≥70% and ≥80% of strains at 6 and 12 h, respectively, and in ≥68% at 24 h.
