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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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Updated: Jun 4, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Current Concepts of Reiter's Syndrome.

Canadian Family Physician Medecin De Famille Canadien

|February 2, 2011

Summary

Reiter's syndrome (RS) is a chronic rheumatic disease diagnosed clinically, often presenting with arthritis and extra-articular features. A positive HLA-B27 test can aid diagnosis when other symptoms are absent.

Area of Science:

Rheumatology
Immunology

Background:

Reiter's syndrome (RS) is a significant rheumatic condition characterized by chronicity and potential long-term morbidity.
Currently, no specific diagnostic test exists for RS, necessitating diagnosis based on clinical presentation.

Purpose of the Study:

To outline the diagnostic challenges and key features of Reiter's syndrome.
To highlight the importance of clinical acumen and supportive diagnostic markers.

Main Methods:

Clinical observation and review of diagnostic criteria for Reiter's syndrome.
Identification of common and atypical presenting symptoms, including arthritis and extra-articular manifestations.
Evaluation of the utility of HLA-B27 testing in diagnosis.

Main Results:

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Last Updated: Jun 4, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

RS diagnosis relies on clinical assessment, often identifying urethritis/cervicitis due to venereal origins.
Extra-articular features like diarrhea, conjunctivitis, and mucocutaneous lesions are common but can be absent.
Arthritis in RS is typically oligoarticular, asymmetrical, and affects lower extremities.
A positive HLA-B27 test is observed in 65-80% of Caucasian RS patients and aids diagnosis when other signs are lacking.

Conclusions:

Reiter's syndrome diagnosis requires careful clinical evaluation, considering a range of articular and extra-articular symptoms.
The HLA-B27 genetic marker serves as a valuable supportive diagnostic tool, particularly in cases with limited clinical manifestations.