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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Cross-reactivity00:42

Cross-reactivity

Overview

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Related Experiment Video

Updated: Jun 4, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Food sensitivities.

P Cutler

    Canadian Family Physician Medecin De Famille Canadien
    |February 2, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Food sensitivities are a common cause of chronic symptoms in allergic patients, often missed by standard allergy tests. Identifying and removing trigger foods typically resolves these symptoms, emphasizing the family doctor

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    Published on: April 21, 2019

    Area of Science:

    • Allergy and Immunology
    • Gastroenterology
    • Family Medicine

    Background:

    • Food sensitivities are a frequent, yet often overlooked, cause of chronic symptoms in patients with diagnosed allergies.
    • Standard allergy testing methods, such as skin testing, frequently fail to detect food sensitivities.
    • Patients experiencing food sensitivity symptoms often present to their family doctor initially.

    Purpose of the Study:

    • To discuss the controversies in managing food sensitivities.
    • To review provocative testing methods, including sublingual and intradermal tests.
    • To highlight the significance of comprehensive patient history, including family history, in diagnosing food sensitivities.

    Main Methods:

    • Review of existing literature and clinical practices regarding food sensitivities.
    • Discussion of provocative sublingual and intradermal testing techniques.
    • Emphasis on the importance of detailed patient interviews for diagnosis.

    Main Results:

    • Food sensitivities are a common cause of unexplained chronic symptoms in allergic individuals.
    • Provocative testing and dietary elimination are key diagnostic and management strategies.
    • Dietary exclusion of identified trigger foods usually leads to symptom resolution.

    Conclusions:

    • Family physicians play a crucial role in the initial detection and management of food sensitivities.
    • A thorough patient history is essential for identifying potential food triggers.
    • Eliminating offending foods from the diet is an effective treatment for food sensitivity symptoms.