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Related Experiment Video

Updated: Jun 4, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

HIV-associated anal cancer.

Thomas Newsom-Davis¹, Mark Bower

¹Department of Oncology, Chelsea and Westminster Hospital NHS Foundation Trust 369 Fulham Road, London SW10 9NH UK.

F1000 Medicine Reports

|February 2, 2011

Summary

Anal cancer, a human papillomavirus-associated malignancy, is significantly more common in individuals with HIV/AIDS. Screening and treatment options exist, but cost-effective national programs are challenging to develop.

Area of Science:

Oncology
Virology
Public Health

Background:

HIV-associated anal carcinoma is a human papillomavirus (HPV)-associated malignancy.
It represents a non-AIDS-defining cancer with preinvasive changes.
The standardized incidence ratio for anal cancer in patients with HIV/AIDS is notably high (20-50).

Purpose of the Study:

To review current strategies for anal cancer screening and treatment in HIV-positive individuals.
To highlight the challenges in establishing cost-effective national screening programs.

Main Methods:

Review of existing algorithms for anal cancer screening.
Description of outpatient topical treatments for anal intraepithelial neoplasia.

Main Results:

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Published on: November 27, 2019

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

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Published on: September 14, 2010

Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Antisense Protein (ASP) RNA Transcripts in Patients by Strand-Specific RT-PCR

Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Antisense Protein (ASP) RNA Transcripts in Patients by Strand-Specific RT-PCR

Published on: November 27, 2019

Screening algorithms typically involve anal cytology followed by high-resolution anoscopy for abnormal results.
Available outpatient treatments for anal intraepithelial neoplasia include infrared coagulation therapy, trichloroacetic acid, and imiquimod.

Conclusions:

Effective screening and treatment modalities for HIV-associated anal cancer are available.
Developing cost-effective national screening programs remains a significant challenge.