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Updated: Jun 4, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
Published on: June 1, 2019
Antigen presentation to B cells
Naomi E Harwood1, Facundo D Batista
1Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK 44 Lincoln's Inn Fields, London WC2A 3LY UK.
Abstract:
B cells are capable of mounting responses to a bewildering range of potentially pathogenic antigens through the production of high-affinity antibodies and the establishment of immunological memory. Thus, regulated B-cell activation is critical for protection against a variety of bacterial and viral infections, as well as cancers. Here, we discuss a number of recent imaging studies that have provided new insights into the variety of mechanisms by which B-cell activation is initiated in the lymph node in vivo.
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