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Plxdc2 is a mitogen for neural progenitors.

Suzanne F C Miller-Delaney1, Ivo Lieberam, Paula Murphy

  • 1Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Plos One
|February 2, 2011
PubMed
Summary

Plxdc2 is identified as a novel regulator of brain development, controlling cell proliferation and neurogenesis. This protein

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Brain region development requires coordinated control of cell proliferation and fate specification.
  • Plxdc2, a type I transmembrane protein, exhibits homology to nidogen and plexins.
  • Plxdc2 expression is dynamic and localized in developing nervous system patterning centers.

Purpose of the Study:

  • To identify novel regulators of neural development.
  • To investigate the role of Plxdc2 in cell proliferation and neurogenesis.
  • To understand the function of Plxdc2 in the developing nervous system.

Main Methods:

  • In ovo electroporation in chick neural tubes.
  • In vitro cultures of mammalian cells, including embryonic neuroepithelial cells (ENCs).
  • Analysis of Plxdc2 expression patterns and functional misexpression.

Main Results:

  • Plxdc2 misexpression increases proliferation and alters neurogenesis, leading to neural tube thickening.
  • The extracellular domain of Plxdc2 is sufficient for cell non-autonomous activity.
  • Plxdc2 induces proliferation in cultured embryonic neuroepithelial cells.

Conclusions:

  • Plxdc2 is a novel regulator of proliferation and neurogenesis in the developing nervous system.
  • Plxdc2 functions in a cell non-autonomous manner.
  • Plxdc2's role in proliferation is relevant to understanding its involvement in certain cancers.

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