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Related Experiment Video

Updated: Jun 4, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Traffic air pollution and oxidized LDL.

Lotte Jacobs1, Jan Emmerechts, Marc F Hoylaerts

  • 1Occupational and Environmental Medicine, Unit of Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium.

Plos One
|February 2, 2011
PubMed
Summary

Traffic air pollution may accelerate atherosclerosis, particularly in individuals with diabetes. Higher exposure to particulate matter, indicated by airway macrophage carbon load and proximity to busy roads, correlated with increased oxidized LDL cholesterol levels.

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Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
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Published on: December 10, 2021

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Last Updated: Jun 4, 2026

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07:29

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Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

Area of Science:

  • Environmental Health
  • Cardiovascular Research
  • Pulmonary Medicine

Background:

  • Epidemiologic studies suggest air pollution accelerates atherosclerosis.
  • Particulate matter (PM) from fossil fuels is a suspected contributor.
  • Patients with diabetes are at high risk for atherosclerosis, making them a key population for study.

Purpose of the Study:

  • To test the hypothesis that individual exposure to fossil fuel-derived PM correlates with plasma oxidized low-density lipoprotein (LDL) levels.
  • To assess the relationship between PM exposure markers and atherosclerosis markers in diabetic patients.

Main Methods:

  • Cross-sectional study of non-smoking adult outpatients with diabetes.
  • Assessed chronic PM exposure via carbon load in airway macrophages (sputum induction) and residential proximity to major roads (geocoding).
  • Regressed exposure indices against plasma oxidized LDL, von Willebrand factor, and plasminogen activator inhibitor 1 (PAI-1).

Main Results:

  • Carbon load in airway macrophages was assessed in 79 subjects.
  • Increased distance from major roads correlated with decreased airway macrophage carbon load.
  • Higher airway macrophage carbon load was associated with increased plasma oxidized LDL.
  • Greater distance from major roads was associated with decreased plasma oxidized LDL.
  • No association found between PM exposure markers and von Willebrand factor or PAI-1.

Conclusions:

  • Plasma oxidized LDL levels were positively associated with airway macrophage carbon load and proximity to busy roads in diabetic patients.
  • These findings suggest a proatherogenic effect of traffic-related air pollution in a susceptible population.