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Updated: Jun 4, 2026

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
Published on: June 14, 2020
Clinical and pathological determinants in tonsillar cancer
Hui-Ching Chuang1, Fu-Min Fang, Chao-Cheng Huang
1Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China.
Background:
The purpose of this study was to present the impact of clinicopathological factors on patient survival in tonsillar squamous cell carcinoma (SCC) that needs to be evaluated.
Method:
This study enrolled 86 patients with tonsillar SCC undergoing surgical resection.
Results:
The cumulative 5-year disease-specific survival (DSS) rate for stages I, II, III, and IVa/b tumors was 100%, 91.7%, 100%, and 61.8%, respectively. Unfavorable cumulative 5-year DSS rates were significantly correlated with advanced T classification (p = .029), tumor thickness over 1 cm (p = .007), 3 or more positive neck lymph nodes (p < .001), and extracapsular spread (ECS; p = .002). Cox regression analysis revealed that the presence of 3 or more positive neck lymph nodes (p = .035) and the stage IVa/b (p = .022) were the independent predictors of the 5-year DSS.
Conclusion:
Patients with tonsillar SCC with stage IVa/b and metastasis to 3 or more lymph nodes have poorer clinical outcomes. Novel therapeutic strategies are necessary for these patients.
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