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Updated: Jun 4, 2026

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
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Engineering ear constructs with a composite scaffold to maintain dimensions.

Libin Zhou1, Irina Pomerantseva, Erik K Bassett

  • 1Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Tissue Engineering. Part A
|February 3, 2011
PubMed
Summary
This summary is machine-generated.

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A novel coiled wire support embedded in porous collagen scaffolds prevents shrinkage in engineered ear cartilage. This innovation maintains construct size and shape, crucial for auricular reconstruction, without hindering neocartilage formation.

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Engineered cartilage for auricular reconstruction faces challenges like construct shrinkage and distortion.
  • Synthetic scaffolds can cause inflammation, while natural scaffolds lack structural integrity against tissue forces.

Purpose of the Study:

  • To evaluate the efficacy of a permanent coiled wire support within porous collagen scaffolds for maintaining ear-shaped construct dimensions.
  • To assess the impact of embedded wire on neocartilage formation and quality in vivo.

Main Methods:

  • Human ear-shaped fibrous collagen scaffolds with and without embedded titanium wire were fabricated.
  • Scaffolds were seeded with sheep auricular chondrocytes and cultured in vitro.
  • Constructs were implanted subcutaneously in nude mice for 6 weeks.

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Last Updated: Jun 4, 2026

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Published on: September 27, 2019

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
08:35

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

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Main Results:

  • Scaffolds with embedded wire showed minimal dimensional changes (2.0% length, 4.1% width).
  • Constructs without wire support exhibited significant shrinkage (14.4% length, 16.5% width).
  • No adverse effects on neocartilage formation or extracellular matrix deposition were observed with wire support.

Conclusions:

  • Embedded coiled wire support is essential for preventing shrinkage in porous collagen ear constructs.
  • This method preserves construct size and shape, overcoming a major hurdle in auricular tissue engineering.
  • The approach supports the development of viable engineered cartilage for reconstructive purposes.