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Prevention of breast cancer: the case for studying inhibition of IGF-1 actions

J Smith1, D Axelrod, B Singh

  • 1Department of Medicine and NYU Cancer Institute, New York, NY 10016, USA. Julia.smith@nyumc.org

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|February 3, 2011
PubMed

Insights

Preventing breast cancer in high-risk women is crucial. New pilot studies are evaluating an insulin-like growth factor-1 pathway inhibitor for breast cancer prevention, with ongoing trials planned.

Area of Science:

  • Oncology
  • Endocrinology
  • Preventive Medicine

Background:

  • High-risk women seek effective breast cancer prevention strategies.
  • Lifestyle and nutritional interventions are difficult to quantify.
  • Current chemoprevention options like tamoxifen and raloxifene have limitations in applicability and acceptance.

Purpose of the Study:

  • To evaluate a potent insulin-like growth factor-1 (IGF-1) pathway inhibitor for breast cancer prevention.
  • To assess the efficacy of IGF-1 inhibition in women with a high genetic susceptibility or clinico-pathologic findings for breast cancer.

Main Methods:

  • Pilot studies involving short-term interventions with an IGF-1 inhibitor.
  • Ongoing evaluation of the inhibitor in women at high risk for breast cancer.

Main Results:

  • Short-term interventions with the IGF-1 inhibitor have been completed.
  • Further interventions are planned to assess long-term efficacy and safety.

Conclusions:

  • The insulin-like growth factor-1 pathway is a promising target for breast cancer prevention.
  • Further research and clinical trials are warranted to establish the role of IGF-1 inhibitors in high-risk populations.

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