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Related Experiment Video

Updated: Jun 4, 2026

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
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Published on: March 29, 2020

Oral masses in two cats.

P Bock1, V Hach, W Baumgärtner

  • 1Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany. patricia.bock@tiho-hannover.de

Veterinary Pathology
|February 3, 2011
PubMed
Summary
This summary is machine-generated.

Two cats were diagnosed with amyloid-producing odontogenic tumors in their oral cavities. These tumors varied in morphology and the specific type of amyloid produced.

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Area of Science:

  • Veterinary Pathology
  • Oral Oncology
  • Biomaterials Science

Background:

  • Odontogenic tumors are rare neoplasms originating from tooth-forming tissues.
  • Amyloid deposition in tumors can alter tissue structure and function.
  • Histological and immunohistochemical analysis are crucial for diagnosing oral neoplasms in felines.

Observation:

  • Two adult cats presented with distinct oral neoplasms: one solitary and well-circumscribed in the mandible, the other diffusely infiltrating in the maxilla.
  • Both tumors exhibited medium-sized epithelial cells within a fibrovascular stroma, with low mitotic activity (0-1 per HPF).
  • Tumor morphologies differed, with nests/streams in one and palisading in the other. Multifocal amyloid accumulation was confirmed via Congo red staining and polarized light microscopy.

Findings:

  • Both feline oral tumors were identified as amyloid-producing odontogenic tumors.
  • Amyloid deposits lacked cytokeratin, AL, and AA amyloid immunoreactivity.
  • Amyloid in one tumor tested positive for odontogenic ameloblast-associated protein (APin).

Implications:

  • This study highlights the occurrence of amyloid-producing odontogenic tumors in cats, expanding the differential diagnosis for feline oral masses.
  • Understanding the varied amyloid composition is vital for accurate diagnosis and potential therapeutic strategies.
  • Further research into the pathogenesis and clinical behavior of these unique feline tumors is warranted.