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Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

Pharmacokinetics in Pediatric Patients: Drug Excretion

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Related Experiment Video

Updated: Jun 4, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Innovative techniques to decrease blood exposure and minimize interruptions in pediatric continuous renal replacement

Dawn M Eding¹, Lindsey R Jelsma, Caryn J Metz

¹Helen DeVos Children's Hospital, 100 Michigan Street, NE, Grand Rapids, MI 49503, USA. Dawn.Eding@devoschildrens.org

Critical Care Nurse

|February 3, 2011

Summary

Continuous renal replacement therapy (CRRT) in children requires special care due to small blood volumes. Innovative techniques minimize blood exposure and instability during CRRT for critically ill pediatric patients.

Related Experiment Videos

Last Updated: Jun 4, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Area of Science:

Pediatric Nephrology
Critical Care Medicine
Renal Replacement Therapy

Background:

Continuous renal replacement therapy (CRRT) enables controlled fluid and solute removal.
Pediatric CRRT demands unique approaches due to smaller blood volumes and risk of hemodynamic instability.
Priming CRRT circuits with blood in children prevents hemodilution but increases risks.

Purpose of the Study:

To introduce and evaluate innovative techniques for pediatric CRRT.
To reduce complications associated with CRRT in critically ill children.
To minimize blood product exposure and therapy interruptions.

Main Methods:

Development and application of a circuit-to-circuit exchange technique for CRRT in infants and small children.
Implementation of a concurrent technique combining CRRT with plasmapheresis.
Focus on managing hemodynamic stability and reducing blood exposure during CRRT.

Main Results:

The circuit-to-circuit exchange technique proved safe and effective for CRRT circuit changes in pediatric patients.
The concurrent CRRT-plasmapheresis technique effectively prevented therapy interruptions.
These methods address challenges of blood priming and instability in pediatric CRRT.

Conclusions:

Innovative CRRT techniques enhance safety and efficacy in critically ill children.
Circuit-to-circuit exchange and concurrent plasmapheresis are valuable alternatives for pediatric CRRT.
These methods improve patient outcomes by minimizing complications and ensuring treatment continuity.