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The oxygen status algorithm: a computer program for calculating and displaying pH and blood gas data.

O Siggaard-Andersen¹, M Siggaard-Andersen

¹University of Copenhagen, Dept. of Clinical Chemistry, Herlev Hospital, Denmark.

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum

|January 1, 1990

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This program analyzes blood gas data to provide a comprehensive laboratory diagnosis of oxygen and acid-base status. It enhances analyzer utility and patient care by calculating derived parameters and offering predictive modeling for therapeutic interventions.

Area of Science:

Medical Informatics
Clinical Chemistry
Respiratory Physiology

Background:

Blood gas analysis is crucial for assessing oxygenation and acid-base balance.
Existing analyzers provide raw data, but derived parameters offer deeper clinical insights.
Predictive modeling can aid in therapeutic decision-making for respiratory and metabolic conditions.

Purpose of the Study:

To develop a software program for comprehensive analysis of blood gas and hemoglobin data.
To calculate derived parameters for a detailed 'laboratory diagnosis' of oxygen and acid-base status.
To enable predictive calculations for therapeutic interventions and serve as a teaching aid.

Main Methods:

Input of arterial blood gas values (pH, pCO2, pO2), hemoglobin fractions, and patient data.

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Utilizes multi-wavelength spectrometry and blood gas analyzer outputs.

Performs calculations for inspired/alveolar oxygen, shunt fraction, oxygen availability, and acid-base parameters.

Main Results:

The program outputs a wide range of derived parameters, including oxygen extraction tension and extracellular base excess.
It generates graphical representations (oxygen graph, acid-base chart, blood gas map) for intuitive data interpretation.
Offers 'reverse' calculations to predict the effects of interventions on patient status.

Conclusions:

The software enhances the diagnostic capabilities of blood gas analyzers and spectrometers.
It improves patient care through detailed status assessment and predictive analysis.
The program serves as a valuable educational tool for understanding acid-base and respiratory physiology.