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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
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Palpation thyroiditis seen on F-18 FDG PET/CT.

John K Blazak1, Aravind S Ravi Kumar

  • 1Queensland PET Service, Royal Brisbane Hospital, Brisbane, Queensland, Australia.

Clinical Nuclear Medicine
|February 3, 2011
PubMed
Summary

Metastatic melanoma was identified in a patient's supraclavicular node and thyroid gland. F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging also revealed findings of palpation thyroiditis, previously undescribed on this scan.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Pathology

Background:

  • Malignant melanoma recurrence can present as new masses.
  • FDG PET/CT is a key imaging modality for melanoma staging and surveillance.
  • Thyroid gland pathologies can exhibit variable FDG uptake.

Observation:

  • A 29-year-old woman with a history of melanoma presented with a supraclavicular mass.
  • FDG PET/CT showed increased uptake in a supraclavicular node and the left thyroid lobe.
  • Histopathology confirmed metastatic melanoma in the node and revealed palpation thyroiditis in the thyroid.

Findings:

  • Metastatic melanoma was confirmed in the supraclavicular lymph node.
  • Palpation thyroiditis was identified in the left thyroid lobe.
  • FDG uptake in thyroid pathologies is common, with 75% being benign.

Implications:

  • This case highlights the potential for FDG PET/CT to detect both melanoma metastasis and benign thyroid conditions.
  • The findings of palpation thyroiditis on FDG PET/CT are novel and expand the imaging spectrum of thyroid conditions.
  • Awareness of these findings is crucial for accurate interpretation of FDG PET/CT in patients with a history of melanoma.