Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contemporary Management of Distal Radius Fractures: What All Plastic Surgeons Should Know.

Plastic and reconstructive surgery·2024
Same author

The Current State of Fat Grafting in the Hand: A Systematic Review for Hand Diseases.

Hand (New York, N.Y.)·2022
Same author

Task-Specific Patient Preferences for Shared Decision-Making in Hand Surgery.

Plastic and reconstructive surgery·2022
Same author

Evaluation of Factors Relevant to Pain Control Among Patients After Surgical Treatment.

JAMA network open·2021
Same author

Trust and Distrust in Opioid Decision-Making: A Qualitative Assessment of Patient-Doctor Relationship.

The Journal of hand surgery·2021
Same author

A Qualitative Study of Patient Protection against Postoperative Opioid Addiction: A Thematic Analysis of Self-Agency.

Plastic and reconstructive surgery·2021
Same journal

Building Practical Artificial Intelligence Tools For The Plastic Surgeon: A Step-By-Step Guide To Cowork.

Plastic and reconstructive surgery·2026
Same journal

Interpretation Matters: Common Statistical Pitfalls in Retrospective Surgical Research.

Plastic and reconstructive surgery·2026
Same journal

"Inferior Repositioning of the High-Riding Nipple Using a Parenchymal-Based Flap".

Plastic and reconstructive surgery·2026
Same journal

A Four-Step Strategy for the Treatment of Facial Rhytids: A Focus on Upper Facial Wrinkles.

Plastic and reconstructive surgery·2026
Same journal

Evaluating Long-Term Retention of Fresh-Frozen Costal Cartilage Allograft in An Animal Model.

Plastic and reconstructive surgery·2026
Same journal

Manual extrusion of fat granules for primary thinning of a bulky flap.

Plastic and reconstructive surgery·2026
See all related articles

Related Experiment Videos

Systematic reviews and meta-analysis.

Steven C Haase1

  • 1Ann Arbor, Mich. From the Section of Plastic Surgery, Department of Surgery, University of Michigan Health System.

Plastic and Reconstructive Surgery
|February 3, 2011
PubMed
Summary
This summary is machine-generated.

Systematic reviews and meta-analyses synthesize medical data for better patient care and research. This guide provides a framework for conducting and critically appraising these important scientific studies.

Related Experiment Videos

Area of Science:

  • Medical Research Methodology
  • Evidence-Based Medicine

Background:

  • Systematic reviews and meta-analyses are crucial tools in modern medicine.
  • They synthesize vast amounts of data for clinical education, patient care improvement, guideline formulation, and research direction.

Purpose of the Study:

  • To provide a comprehensive guide for conducting systematic reviews.
  • To outline a framework for critical appraisal of published systematic reviews.
  • To address the application of systematic review findings to individual patient care.

Main Methods:

  • Review of existing literature on systematic reviews and meta-analyses.
  • Inclusion of recently updated guidelines and reporting standards.
  • Summarization of best practices and illustrative examples.

Main Results:

  • A historical overview of systematic reviews.
  • Discussion of the advantages and disadvantages of systematic reviews.
  • A step-by-step guide for conducting systematic reviews, including reporting guidelines.

Conclusions:

  • Presents a framework for conducting and critically appraising systematic reviews using clinical examples and guidelines.
  • Emphasizes the importance of applying systematic review results to individual patient care.
  • Aims to enhance the quality and utility of systematic reviews in medical research and practice.