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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Functional impairment in the diagnosis of mild cognitive impairment

Ji Won Han1, Seok Bum Lee, Tae Hui Kim

  • 1Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea.

Alzheimer Disease and Associated Disorders
|February 3, 2011
PubMed

Insights

The functional activity criterion for mild cognitive impairment (MCI) is problematic. Patients meeting this criterion had significantly lower dementia conversion rates, suggesting a need for diagnostic revision.

Area of Science:

  • Neurology
  • Gerontology
  • Psychiatry

Background:

  • The revised diagnostic criteria for mild cognitive impairment (MCI) include a functional activity criterion.
  • This criterion has been noted as potentially problematic in its conceptualization and application.

Purpose of the Study:

  • To evaluate the predictive validity of the functional activity criterion for dementia conversion in MCI patients.
  • To assess the operational ambiguities of the functional activity criterion in diagnosing MCI.

Main Methods:

  • Analysis of 140 MCI patients from the Korean Longitudinal Study on Health and Aging.
  • Comparison of annual dementia conversion rates between patients who met and did not meet the functional activity criterion over an 18-month follow-up.

Main Results:

  • Patients meeting the functional activity criterion showed a 4.76% annual dementia conversion rate.
  • Patients not meeting the criterion had a significantly higher annual conversion rate of 33.07%.
  • The functional activity criterion was a significant negative predictor of dementia (OR=0.12).

Conclusions:

  • The current functional activity criterion for MCI appears to have limited predictive validity for dementia.
  • Conceptual and operational ambiguities in the functional activity criterion necessitate re-revision for improved diagnostic accuracy.

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