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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Related Experiment Video

Updated: Jun 4, 2026

Electrophysiology of Scorpion Peg Sensilla
07:50

Electrophysiology of Scorpion Peg Sensilla

Published on: April 13, 2011

The sting.

J H Day

    Canadian Family Physician Medecin De Famille Canadien
    |February 3, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Insect sting anaphylaxis affects 0.4% of people, with venom immunotherapy showing 95% efficacy. Allergy testing, including IgE and IgG antibodies, monitors treatment effectiveness for hymenoptera allergies.

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    Captive Maintenance and Venom Extraction of Tityus serrulatus (Brazilian Yellow Scorpion) for Antivenom Production
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    Captive Maintenance and Venom Extraction of Tityus serrulatus (Brazilian Yellow Scorpion) for Antivenom Production

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    Last Updated: Jun 4, 2026

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    Captive Maintenance and Venom Extraction of Tityus serrulatus (Brazilian Yellow Scorpion) for Antivenom Production
    05:27

    Captive Maintenance and Venom Extraction of Tityus serrulatus (Brazilian Yellow Scorpion) for Antivenom Production

    Published on: October 6, 2023

    Area of Science:

    • Allergy and Immunology
    • Toxicology
    • Public Health

    Background:

    • Anaphylactic reactions to insect stings affect approximately 0.4% of the general population.
    • Individuals with a family history of beekeeping have a higher prevalence, up to 20%, of experiencing these reactions.
    • Systemic reactions can escalate in severity with repeated stings, and insect stings cause an estimated four to five deaths annually in Canada.

    Purpose of the Study:

    • To evaluate the effectiveness of venom immunotherapy for treating insect sting allergies.
    • To assess the utility of various diagnostic tests in managing hymenoptera allergies.
    • To provide insights into the epidemiology and clinical course of anaphylaxis due to insect stings.

    Main Methods:

    • Review of efficacy data for venom immunotherapy.
    • Analysis of diagnostic methods including skin tests, in vitro assessment of venom-specific IgE (allergy antibody) and IgG (blocking antibody).
    • Evaluation of leukocyte histamine release assays as a diagnostic and monitoring tool.

    Main Results:

    • Venom immunotherapy demonstrates a high efficacy rate of approximately 95%.
    • Skin tests and in vitro assessments of IgE and IgG antibodies are valuable for diagnosing hymenoptera allergy.
    • Leukocyte histamine release assays serve as effective monitors for treatment effectiveness.

    Conclusions:

    • Venom immunotherapy is a highly effective treatment for insect sting-induced anaphylaxis.
    • Allergy testing, including specific IgE and IgG antibody measurements, is crucial for diagnosis and monitoring treatment.
    • Understanding the epidemiology and utilizing appropriate diagnostic tools can improve patient outcomes for hymenoptera allergies.