Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Electrophysiology of Normal Cardiac Rhythm

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Pulse rhythm

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Mechanism of Cardiac Arrhythmias

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Myocardial relaxation, left ventricular filling, and exercise capacity in older subjects with dyspnea.

American journal of physiology. Heart and circulatory physiology·2026

Same author

Voltage and propagation mapping: New tools to improve successful ablation of atrioventricular nodal reentry tachycardia.

Journal of cardiovascular electrophysiology·2024

Same author

Can specific ECG markers identify a pharmacologically induced type 1 Brugada pattern? Insights from a large, single-center cohort.

Journal of electrocardiology·2023

Same author

[Cardiac contractility modulation therapy: molecular mechanisms and rationale for clinical application in heart failure with systolic and diastolic dysfunction].

Giornale italiano di cardiologia (2006)·2023

Same author

Proarrhythmic effect of bipolar epicardial left ventricular stimulation in CRT resolved maintaining biventricular pacing with unipolar-cathodical configuration: A peculiar case report.

Journal of arrhythmia·2023

Same author

Endocardial ablation of epicardial ganglionated plexi: history, open questions and future prospects of cardioneuroablation.

Minerva cardiology and angiology·2022

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Future easy and physiological cardiac pacing.

Eraldo Occhetta¹, Miriam Bortnik, Paolo Marino

¹Eraldo Occhetta, Miriam Bortnik, Paolo Marino, Division of Cardiology, "Maggiore della Carità" Hospital, University of Eastern Piedmont, 28100 Novara, Italy.

World Journal of Cardiology

|February 3, 2011

Summary

This summary is machine-generated.

New pacing techniques using active screw-in leads offer physiological atrial and right ventricular pacing. These methods, including septal atrial and para-Hisian pacing, may improve outcomes and prevent atrial fibrillation in patients requiring frequent cardiac pacing.

Keywords:

Atrial septum Cardiac pacing Parahisian pacing

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Related Experiment Videos

Last Updated: Jun 4, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Area of Science:

Cardiology
Biomedical Engineering

Background:

Conventional dual-chamber atrio-ventricular cardiac (DDD) pacing sites, the right atrial appendage (RAA) and right ventricular apex (RVA), have limitations.
RAA pacing may not prevent atrial fibrillation in tachycardia-bradycardia syndrome.
RVA pacing can induce left bundle branch block-like activation with negative consequences.

Purpose of the Study:

To review the benefits of novel pacing sites and technologies for cardiac pacing.
To highlight the advantages of physiological pacing over conventional methods.

Main Methods:

Review of current literature on cardiac pacing lead technologies and implantation sites.
Analysis of physiological pacing effects, including septal atrial and para-Hisian pacing.

Main Results:

Active screw-in leads enable more physiological atrial and right ventricular pacing.
Septal atrial lead pacing results in shorter, more homogeneous atrial activation, aiding atrial fibrillation prevention.
Para-Hisian pacing offers a simpler, more reliable alternative to biventricular and direct Hisian pacing.

Conclusions:

New pacing strategies utilizing septal atrial and para-Hisian sites offer physiological benefits.
These "easy and physiological pacing" approaches show promise for patients needing frequent cardiac pacing.
Larger trials are needed to establish these methods as a first-line approach.