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Updated: Jun 4, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Sleep duration and circulating adipokine levels.

Amanda L Hayes¹, Fang Xu, Denise Babineau

¹Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA.

|February 3, 2011

Summary

This summary is machine-generated.

Short sleep duration is linked to higher levels of leptin and visfatin, adipokines associated with inflammation and insulin resistance. Reduced REM sleep also elevates these hormones, suggesting a connection between sleep quality and metabolic health.

Keywords:

Sleep duration adipokine adipose tissue insulin resistance leptin obesity retinol binding protein-4 visfatin

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Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

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Published on: April 7, 2020

Area of Science:

Endocrinology
Sleep Medicine
Metabolic Health

Background:

Short sleep duration is a known risk factor for systemic inflammation and diabetes.
The precise mechanisms linking reduced sleep to these conditions remain unclear.
Adipocyte-derived hormones (adipokines) may mediate the relationship between sleep, inflammation, and insulin resistance.

Purpose of the Study:

To investigate the association between sleep duration and the levels of three key adipokines: leptin, visfatin, and retinol binding protein-4 (RBP4).

Main Methods:

Utilized polysomnography to measure sleep duration in 561 adults from the Cleveland Family Study.
Assayed fasting morning blood samples for leptin, visfatin, and RBP4 levels.
Performed statistical analyses adjusted for various demographic, clinical, and sleep-related factors.

Main Results:

Each hour reduction in total sleep time (TST) was associated with increased leptin and visfatin levels, even after adjusting for confounders.
Reduced REM sleep was significantly linked to higher leptin and visfatin concentrations.
No significant association was found between sleep duration and RBP4 levels.

Conclusions:

Reduced total sleep time and reduced REM sleep are independently associated with elevated levels of leptin and visfatin.
These findings suggest a potential role for adipokines in mediating the adverse metabolic effects of insufficient sleep.
Further research into sleep's impact on adipose tissue function is warranted.