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A case of malignant hyperthermia during anesthesia induction with sevoflurane -A case report-

Yoon Sook Lee1, Woon Young Kim, Se Hwa Lee

  • 1Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Ansan, Korea.

Korean Journal of Anesthesiology
|February 3, 2011
PubMed

Insights

Malignant hyperthermia (MH) occurred in a child during anesthesia. Early recognition and treatment with dantrolene successfully managed this rare but serious adverse event.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Malignant hyperthermia (MH) is a rare, life-threatening pharmacogenetic disorder of skeletal muscle.
  • While often associated with succinylcholine, volatile anesthetics like sevoflurane can also trigger MH, sometimes with delayed onset.

Purpose of the Study:

  • To report a case of sevoflurane-induced malignant hyperthermia in a pediatric patient.
  • To highlight the importance of early recognition and prompt management of MH during anesthesia.

Main Methods:

  • A 6-year-old boy developed MH during anesthesia induction for strabismus surgery.
  • Sevoflurane was administered with nitrous oxide, oxygen, and rocuronium.
  • The patient received symptomatic treatment and dantrolene.

Main Results:

  • Malignant hyperthermia was triggered approximately 2-3 minutes after sevoflurane administration.
  • The patient's condition was successfully treated with early recognition and administration of dantrolene and supportive care.

Conclusions:

  • Sevoflurane can induce malignant hyperthermia even without succinylcholine.
  • Prompt diagnosis and dantrolene administration are critical for successful management of MH.
  • Vigilance for MH is essential in pediatric anesthesia, particularly when using volatile agents.
Keywords:
DantroleneMalignant hyperthermiaSevoflurane

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