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Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Depressants01:28

Depressants

Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...

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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Published on: June 23, 2023

Does timing of alcohol administration affect sleep?

Eliza Van Reen1, Leila Tarokh, Tracy L Rupp

  • 1Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI.

Sleep
|February 3, 2011
PubMed
Summary

Alcohol may disrupt sleep, but a low dose does not aid sleep at adverse circadian times. Further research is needed to understand alcohol

Keywords:
EEGSleepalcoholforced desynchronytiming

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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
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Last Updated: Jun 4, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Area of Science:

  • Sleep research
  • Chronobiology
  • Pharmacology

Background:

  • Alcohol consumption is widespread, and its effects on sleep are of significant interest.
  • Understanding the circadian timing of alcohol administration is crucial for assessing its impact on sleep quality and architecture.
  • Previous studies have yielded mixed results regarding alcohol's effects on sleep, necessitating further investigation into specific timing and dosage parameters.

Purpose of the Study:

  • To investigate the influence of alcohol administration at different times of day on sleep patterns.
  • To examine how varying homeostatic sleep pressure interacts with the circadian timing of alcohol to affect sleep.
  • To determine if low-dose alcohol can serve as a sleep aid, particularly during circadian phases unfavorable for sleep.

Main Methods:

  • A 20-hour forced desynchrony (FD) protocol was employed with 26 healthy young adults (21-25 years).
  • Participants received placebo or alcohol (targeting 0.05g% BAC) at four different clock times (0400, 1000, 1600, 2200).
  • Alcohol was administered under low, medium, and high homeostatic sleep load conditions, with sleep monitored via spectral analysis.

Main Results:

  • Breath Alcohol Concentration (BrAC) confirmed target levels, with measurable BrAC at bedtime only under high homeostatic load.
  • Alcohol did not significantly alter the spectral characteristics of sleep across different administration times.
  • Minor changes in sleep stages were observed, with a notable increase in wakefulness when alcohol was given at 0400 under high homeostatic load.

Conclusions:

  • The study suggests that alcohol can be disruptive to sleep, although the specific mechanisms and timing-dependent effects require further elucidation.
  • Findings do not support the use of low-dose alcohol as a sleep aid, especially when attempting to sleep during an adverse circadian phase.
  • Circadian timing and homeostatic sleep pressure are critical factors to consider when evaluating alcohol's impact on sleep.