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Updated: Aug 8, 2026

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
Biological activity of gamma interferon
F Dianzani1, G Antonelli, M R Capobianchi
1Istituto di Virologia, Università degli Studi La Sapienza, Rome, Italy.
Abstract:
Gamma interferon (IFN) is mainly produced, under natural conditions, by antigen-specific T lymphocytes during the immune response. Cooperation with macrophages is required. Although discovered in 1965 as an antiviral agents, today this type of IFN is considered a lymphokine deeply involved in the regulation of several immunological reactions such as: cytotoxicity; expression of surface antigens, mainly MHC antigens; cellular differentiation; antibody production; macrophage activation. In this review the authors discuss some aspects of the biology of gamma IFN as pleiotropic lymphokine as well as the cellular events leading to gamma IFN production.
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