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Biological surface modification of titanium surfaces using glow discharge plasma.
Haw-Ming Huang1, Sung-Chih Hsieh, Nai-Chia Teng
1School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Medical & Biological Engineering & Computing
|February 3, 2011
Summary
Glow discharge plasma treatment enhances titanium
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Biomedical Engineering
Background:
- Titanium's biological activity is crucial for implants.
- Improving titanium's osseointegration and biocompatibility is an ongoing challenge.
Purpose of the Study:
- To enhance the bioactivity of titanium disks.
- To investigate the effects of albumin grafting using glow discharge plasma (GDP).
Main Methods:
- Titanium disks were pre-treated with GDP using argon and allylamine gas.
- Albumin was grafted onto the titanium surface using glutaraldehyde as a cross-linker.
- Surface characterization included SEM, XPS, and water contact angle measurements.
- MG-63 osteoblast-like cells were cultured to assess cell behavior and blood coagulation resistance.
Main Results:
- Albumin-grafted titanium showed improved surface wettability.
- MG-63 cells exhibited enhanced differentiated morphology on modified surfaces.
- The modified titanium demonstrated significantly reduced thrombus formation, indicating improved blood coagulation resistance.
Conclusions:
- GDP-mediated albumin grafting effectively improves titanium's surface properties.
- This surface modification enhances cellular response and reduces blood clot formation.
- GDP holds potential for improving the biofunctionality of titanium-based medical devices.
