Related Experiment Videos
L5178Y mouse lymphoma cell mutation assay results with 41 compounds
1Department of Molecular and Cellular Toxicology, Hazleton Laboratories of America, Kensington, Maryland.
Environmental and Molecular Mutagenesis
|January 1, 1990
Summary
The mouse lymphoma assay (MOLY) demonstrated a 69% concordance with rodent carcinogenicity predictions when equivocal results were excluded. This study assessed trifluorothymidine resistance induction by 41 chemicals.
Area of Science:
- Toxicology
- Genotoxicity Testing
- Carcinogenicity Prediction
Background:
- The National Toxicology Program (NTP) evaluates in vitro assays for predicting rodent carcinogenicity.
- The L5178Y mouse lymphoma (MOLY) assay is one such in vitro test.
- Assessing the reliability of in vitro assays is crucial for efficient toxicological screening.