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Updated: Jun 4, 2026

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
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Corneal epithelialisation on surface-modified hydrogel implants: artificial cornea.

Aihua Ma1, Bojun Zhao, Adam J Bentley

  • 1School of Health and Medicine, Biomedical and Life Sciences, Lancaster University, Lancaster, UK.

Journal of Materials Science. Materials in Medicine
|February 3, 2011
PubMed
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Surface-modified polymethacrylate hydrogels show promise for artificial corneas. Specifically, 1,4-diaminobutane modification and collagen IV coating enabled full corneal epithelialisation, suggesting clinical potential.

Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Tissue Engineering

Background:

  • Corneal diseases necessitate advanced treatments, including artificial cornea development.
  • Polymethacrylate hydrogels are explored for their biocompatibility and potential in ocular prosthetics.
  • Surface modification is crucial for enhancing cellular integration and tissue regeneration on biomaterials.

Purpose of the Study:

  • To evaluate surface-modified polymethacrylate hydrogels as potential artificial cornea materials.
  • To investigate the corneal re-epithelialisation capacity of these modified hydrogels.
  • To assess the integration and clarity of hydrogel implants in a corneal model.

Main Methods:

  • Polymethacrylate hydrogels were modified with various amines (e.g., 1,4-diaminobutane) and coated with extracellular matrix proteins (collagen I, IV, laminin, fibronectin).

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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Published on: September 12, 2014

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Last Updated: Jun 4, 2026

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

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Published on: July 10, 2018

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

  • Modified hydrogels were surgically implanted into bovine corneas cultured in a 3-D system for 5 days.
  • Epithelial growth was assessed using fluorescent, light, and electron microscopy.

    • Main Results:

    • Complete epithelialisation was achieved on 1,4-diaminobutane-modified hydrogels coated with collagen IV.
    • Partial re-epithelialisation occurred on hydrogels modified with 1,4-diaminobutane alone or other amines without optimal coating.
    • Implants with 1,4-diaminobutane modification and collagen IV coating maintained corneal clarity and integrated well, supporting stratified epithelium growth.

    Conclusions:

    • 1,4-diaminobutane surface-modified hydrogels coated with collagen IV effectively support stable stratified epithelium growth.
    • These findings indicate that this specific hydrogel modification holds significant potential for clinical application as an artificial cornea.
    • Further refinement of this hydrogel material could lead to improved outcomes in corneal regenerative medicine.