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Updated: Aug 15, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

[Viral oncogens and carcinogenesis]

V M Zhdanova, A D Al'tshteĭn

    Voprosy Onkologii
    |January 1, 1978
    PubMed

    Insights

    This study explores virus oncogenes, discussing their identification and protein products from polyoma, adeno, and oncoviruses. Research suggests a cellular origin for these viral oncogenes, potentially aiding in identifying cancer-causing genes.

    Area of Science:

    • Virology
    • Molecular Biology
    • Oncology

    Context:

    • Discusses modern concepts of tumorigenic virus oncogenes.
    • Reviews literature on oncogene identification in polyoma, adeno, and oncoviruses.
    • Examines the protein products of identified viral oncogenes.

    Purpose:

    • To explore the cellular origin of virus oncogenes.
    • To present available literature data on viral oncogenes and their protein products.
    • To suggest new methods for identifying cellular genes involved in malignancy.

    Summary:

    • Investigates viral oncogenes, including their identification and protein products from various oncoviruses.
    • Considers the hypothesis that virus oncogenes originate from cellular genes.
    • Proposes that studying viral oncogenes can lead to novel approaches for identifying cellular genes causing cancer.

    Impact:

    • Offers new methodical approaches for identifying cellular genes responsible for malignancy.
    • Enhances understanding of the relationship between viral and cellular genes in cancer development.
    • Provides a foundation for future research into oncogene-driven tumorigenesis.

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