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Antimicrobial activity of artemisinin and its derivatives against anaerobic bacteria
H A Shoeb1, A F Tawfik, A M Shibl
1Department of Pharmaceutics and Microbiology, College of Pharmacy, King Saud University, Saudi Arabia.
Journal of Chemotherapy (Florence, Italy)
|December 1, 1990
Abstract:
Artemisinin and nine of its semisynthetic derivatives were tested for antibacterial activity against anaerobic, facultative anaerobic, microaerophilic and aerobic bacteria. Only anaerobic bacteria and gonococci showed sensitivity to artemisinin derivatives. Artemisinin and its deoxy derivatives had no activity at 100 micrograms/ml concentration. The newly synthesized methyl diperoxy derivative had the highest activity against all tested anaerobes with a MIC of 9.4 micrograms/ml.