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[Association of haptoglobin 1/2 polymorphism with coronary heart disease in Chinese]

Hai-bo Liu1, Yu-ping Shi, Xiao-fang Guo

  • 1Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009 PR China.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|February 3, 2011
PubMed

Insights

The haptoglobin (HP) 2-2 genotype is linked to a higher risk of coronary heart disease (CHD) in Chinese individuals. This genotype may serve as an independent risk factor for developing CHD.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • Haptoglobin (HP) polymorphism is a potential factor influencing cardiovascular health.
  • Understanding genetic predispositions like HP polymorphism is crucial for identifying coronary heart disease (CHD) risk factors.

Purpose of the Study:

  • To investigate the association between haptoglobin (HP) 1/2 polymorphism and the prevalence of coronary heart disease (CHD) in the Chinese Han population.

Main Methods:

  • Genotyping of haptoglobin (HP) 1 and HP 2 alleles using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
  • Comparison of genotype frequencies between 189 CHD patients and 242 healthy controls confirmed by angiography.

Main Results:

  • The HP2-2 genotype was significantly more frequent in CHD patients (0.54) compared to controls (0.35), indicating a strong association (P=0.000).
  • The HP2-2 genotype was identified as an independent risk factor for CHD, increasing risk by approximately 2.1-fold (OR=2.101, P=0.002).
  • A higher frequency of the HP2 allele was observed in the CHD group (0.74) versus controls (0.61) (P=0.000).

Conclusions:

  • The HP2-2 genotype is significantly associated with coronary heart disease (CHD) in the Chinese population.
  • HP2-2 genotype may represent an independent risk factor for CHD.
  • The HP2 allele might be a genetic susceptibility factor for CHD in Chinese individuals.
Abstract

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