Quantitative cerebral blood flow in dynamic susceptibility contrast MRI using total cerebral flow from phase contrast...

Dynamic susceptibility contrast magnetic resonance imaging during bolus injection of gadolinium contrast agent is commonly used to investigate cerebral hemodynamics. The large majority of clinical applications of dynamic susceptibility contrast magnetic resonance imaging to date have reported relative cerebral blood flow values because of dependence of the result on the accuracy of determining the arterial input function, the robustness of the singular value decomposition algorithm, and others. We propose a calibration approach that directly measures the total (i.e., whole brain) cerebral blood flow in individual subjects using phase contrast magnetic resonance angiography. The method was applied to data from 11 patients with intracranial pathology. The sum of squares variance about the mean (uncorrected: white matter = 105.6, gray matter = 472.2; corrected: white matter = 34.1, gray matter = 99.8) after correction was significantly lower for white matter (P = 0.045) and for gray matter (P = 0.011). However, the mean gray and white matter cerebral blood flow in the contralateral hemisphere were not significantly altered by the correction. The proposed phase contrast magnetic resonance angiography calibration technique appears to be one of the most direct correction schemes available for dynamic susceptibility contrast magnetic resonance imaging cerebral blood flow values and can be performed rapidly, requiring only a few minutes of additional scan time.