Related Experiment Video
Updated: Jun 4, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Effect of antiviral amantadine treatment on elderly chronic schizophrenia patients
Boris Finkel1, Craig Goodman, Yuval Melamed
1Psychogeriatric Department, Lev HaSharon Mental Health Center, Netanya, Israel. bfinkel@lev-hasharon.co.il
Background:
In compliance with public health measures initiated by the Israel Ministry of Health following an outbreak of influenza, amantadine was administered to all patients in the psychogeriatric department of Lev Hasharon Mental Health Center to reduce transmission and illness severity in this susceptible population.
Objectives:
To evaluate the potential beneficial effects of amantadine on elderly hospitalized patients with persistent schizophrenia.
Methods:
We conducted a retrospective case review of the treatment effects of amantadine on the mental, cognitive and clinical states of elderly chronic schizophrenic patients who received concomitant amantadine treatment and were routinely evaluated with the Positive and Negative Syndrome Scale, the Mini Mental State Examination, and Sandoz Clinical Assessment Geriatric Scale.
Results:
No significant differences before and after amantadine treatment were noted.
Conclusion:
Amantadine did not influence the mental, cognitive and clinical states of elderly schizophrenia patients and thus can be considered as an anti-influenza preventive measure for this population, when indicated.
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Pharmacodynamics in Geriatric Patients: Effects of Age
Alzheimer's Disease: Treatment
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Psychosis: Goals of Pharmacotherapy
