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Modification of transformation of C3H/10T1/2 cells by a differentiation-inducing substance
1Institute of Biology, Research Centre Seibersdorf, Austria.
Acta Biologica Hungarica
|January 1, 1990
Abstract:
Transformation of C3H/10T1/2 cells was induced by 3-methylcholanthrene. Treatment with hexamethylene bisacetamide (HMBA), a differentiation inducing and poly (ADP-ribose)-synthesis modifying substance, influences expression of multilayered foci in a treatment schedule-dependent manner. Inhibition of transformation occurred only if HMBA was present after the genotoxic damage. After HMBA treatment most of transformed cells showed an end-differentiation like form.