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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Updated: Jun 4, 2026

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Stem cells in cardiovascular disease.

Arshed A Quyyumi¹, Jonathan Murrow

¹Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. aquyyum@emory.edu

Medicinski Arhiv

|February 4, 2011

Summary

Stem cell therapies show promise for cardiovascular diseases, improving heart function in preclinical studies. Human trials indicate modest efficacy and good safety, supporting further research into these innovative treatments.

Area of Science:

Cardiovascular Biology
Regenerative Medicine
Stem Cell Therapy

Background:

Recent advances in stem cell biology have spurred interest in novel therapies for cardiovascular diseases.
Preclinical research indicates potential benefits of various cell types for improving cardiac ischemia and function.
Mechanisms underlying stem cell efficacy in cardiovascular repair require further elucidation.

Purpose of the Study:

To review the current state of stem cell therapies for cardiovascular diseases.
To assess the efficacy and safety of stem cell treatments based on preclinical and clinical data.
To highlight the need for continued research in this field.

Main Methods:

Review of preclinical studies investigating stem cell effects on ischemia and ventricular function.

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Analysis of human clinical trials evaluating stem cell therapy for cardiovascular conditions.

Synthesis of evidence regarding the safety and efficacy of experimental cardiovascular cell therapies.

Main Results:

Preclinical models suggest stem cells can improve cardiac ischemia and ventricular function.
Human studies demonstrate modest clinical efficacy with certain cell types.
The safety profile of these experimental therapies is generally favorable.

Conclusions:

Stem cell therapy holds potential for treating acute and chronic cardiovascular diseases.
Further patient-oriented research is warranted to optimize efficacy and fully understand mechanisms.
The established safety supports continued investigation in clinical settings.