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Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jun 4, 2026

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

Quiescence regulators for hematopoietic stem cell.

¹Department of Genetics, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. jli@mdanderson.org

Experimental Hematology

|February 4, 2011

Summary

This summary is machine-generated.

Hematopoietic stem cells (HSCs) maintain a quiescent state to ensure a lifelong supply of blood cells and prevent mutations. Understanding HSC quiescence regulation is key to both normal physiology and disease.

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Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Published on: December 9, 2022

Area of Science:

Hematology
Stem Cell Biology
Cell Cycle Regulation

Background:

Hematopoietic stem cells (HSCs) balance self-renewal, differentiation, and quiescence to maintain blood cell production throughout life.
HSC quiescence is vital for preserving the stem cell pool and minimizing replication-associated mutations.
Both intrinsic and extrinsic factors tightly regulate the balance between HSC quiescence and proliferation.

Purpose of the Study:

To review recent advances in identifying molecules and pathways that regulate hematopoietic stem cell quiescence.
To highlight the importance of understanding HSC quiescence for both physiological and pathophysiological contexts.

Main Methods:

Review of reductionistic strategies used to identify HSC quiescence regulators.
Analysis of identified positive and negative regulators within the HSC quiescence network.

Main Results:

Numerous molecules and pathways critical for HSC quiescence regulation have been identified.
The regulatory network involves complex interactions of both positive and negative regulators.

Conclusions:

Understanding HSC quiescence regulation is crucial for comprehending stem cell physiology.
Insights into HSC quiescence are essential for understanding the origins of related hematological disorders.