Related Experiment Video
Updated: Jun 4, 2026

Synthesis of an In vivo MRI-detectable Apoptosis Probe
Published on: July 31, 2012
A novel artificial superoxide dismutase: non-covalent conjugation of albumin with a Mn(III) salophen type complex
Valentina Oliveri1, Graziella Vecchio
1Dipartimento di Scienze Chimiche, University of Catania, Vle ADoria 6, 95125 Catania, Italy.
Abstract:
The approach of non-covalent conjugation has recently been used and a number of metal complexes have been encaged in a protein scaffold to form functional metallo proteins. Here we investigate a novel artificial superoxide dismutase enzyme based on the non-covalent conjugation of bovine serum albumin and the manganese(III) complex of N,N'-bis(salicylidene)-3,4-diaminobenzoic acid. We report the intriguing ability of the albumin environment to increase the SOD activity of the inorganic complex. We also determined the binding constant with BSA by CD spectroscopy.
Related Concept Videos
The Supercomplexes in the Crista Membrane
Formation of Complex Ions
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

