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Prevalence of wasting among under 6-month-old infants in developing countries and implications of new case
Marko Kerac1, Hannah Blencowe, Carlos Grijalva-Eternod
1Centre for International Health and Development, UCL Institute of Child Health, London, UK. marko.kerac@gmail.com
Insights
New World Health Organization (WHO) standards significantly increase the estimated prevalence of wasting in infants under 6 months. This highlights a greater disease burden, especially for severe wasting, requiring policy consideration.
Area of Science:
- Global child health
- Pediatric nutrition
- Public health surveillance
Background:
- Infant wasting is a critical global health issue.
- Accurate prevalence data is essential for effective interventions.
- Growth references impact disease burden estimation.
Purpose of the Study:
- To determine wasting prevalence in infants under 6 months.
- To assess the impact of new World Health Organization (WHO) growth standards on prevalence estimates.
- To compare wasting prevalence using WHO standards versus National Center for Health Statistics (NCHS) references.
Main Methods:
- Secondary analysis of Demographic and Health Survey data.
- Inclusion of 15,534 infants under 6 months and 147,694 children aged 6 to 59 months from 21 developing countries.
- Wasting defined by weight-for-height z-scores (<-2), with moderate wasting (-3 to <-2) and severe wasting (<-3).
Main Results:
- WHO standards more than double infant wasting prevalence compared to NCHS references (median 15% vs 3.7%).
- Estimated number of wasted infants under 6 months increases from ~3 million to ~8.5 million globally.
- The increase in prevalence, particularly for severe wasting, is more pronounced in infants under 6 months than in older children.
Conclusions:
- Wasting is prevalent among infants under 6 months in developing countries, regardless of the reference standard used.
- Adoption of WHO standards significantly increases the estimated disease burden of infant wasting.
- Policymakers and health programs must consider the implications of changing case definitions on resource allocation and risk assessment.
Objectives:
To determine wasting prevalence among infants aged under 6 months and describe the effects of new case definitions based on WHO growth standards.
Design:
Secondary data analysis of demographic and health survey datasets.
Setting:
21 developing countries.
Population:
15 534 infants under 6 months and 147 694 children aged 6 to under 60 months (median 5072 individuals/country, range 1710-45 398). Wasting was defined as weight-for-height z-score <-2, moderate wasting as -3 to <-2 z-scores, severe wasting as z-score <-3.
Results:
Using National Center for Health Statistics (NCHS) growth references, the nationwide prevalence of wasting in infant under-6-month ranges from 1.1% to 15% (median 3.7%, IQR 1.8-6.5%; ∼3 million wasted infants <6 months worldwide). Prevalence is more than doubled using WHO standards: 2.0-34% (median 15%, IQR 6.2-17%; ∼8.5 million wasted infants <6 months worldwide). Prevalence differences using WHO standards are more marked for infants under 6 months than children, with the greatest increase being for severe wasting (indicated by a regression line slope of 3.5 for infants <6 months vs 1.7 for children). Moderate infant-6-month wasting is also greater using WHO, whereas moderate child wasting is 0.9 times the NCHS prevalence.
Conclusions:
Whether defined by NCHS references or WHO standards, wasting among infants under 6 months is prevalent in many of the developing countries examined in this study. Use of WHO standards to define wasting results in a greater disease burden, particularly for severe wasting. Policy makers, programme managers and clinicians in child health and nutrition programmes should consider resource and risk/benefit implications of changing case definitions.
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