Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 4, 2026

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Readily available tissue-engineered vascular grafts.

Shannon L M Dahl1, Alan P Kypson, Jeffrey H Lawson

  • 1Humacyte Inc., Durham, NC 27709, USA. dahl@humacyte.com

Science Translational Medicine
|February 4, 2011
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury.

Circulation research·2026
Same author

Reply: Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers.

JACC. Basic to translational science·2026
Same author

Long-term safety and efficacy outcomes of the Acellular Tissue Engineered Vessel (ATEV) in extremity arterial trauma repair.

Journal of vascular surgery cases and innovative techniques·2025
Same author

Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model.

JVS-vascular science·2025
Same author

Short-term performance of Symvess (acellular tissue engineered vessel-tyod) compared to external control data for autologous vein in treatment of extremity arterial injury.

Trauma surgery & acute care open·2025

Tissue-engineered vascular grafts using decellularized cells on scaffolds offer a promising alternative for patients needing hemodialysis access or arterial bypass. These non-immunogenic grafts show excellent patency and durability in preclinical models.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Vascular Surgery

Background:

  • Vascular grafts are crucial for hemodialysis access and arterial bypass.
  • Limitations exist with autologous tissues and synthetic grafts.
  • Tissue engineering offers a potential solution for graft alternatives.

Purpose of the Study:

  • To engineer vascular grafts using decellularized allogeneic or xenogeneic cells on scaffolds.
  • To evaluate the mechanical properties and storage stability of engineered grafts.
  • To assess the in vivo performance of engineered grafts in preclinical models.

Main Methods:

  • Human or canine smooth muscle cells cultured on polyglycolic acid scaffolds.
  • Decellularization process to create non-immunogenic grafts.

More Related Videos

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring
11:17

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Published on: April 3, 2015

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Related Experiment Videos

Last Updated: Jun 4, 2026

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring
11:17

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Published on: April 3, 2015

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

  • Mechanical testing, long-term storage evaluation, and in vivo implantation in baboon and dog models.

    • Main Results:

    • Engineered human grafts exhibited mechanical properties comparable to native vessels.
    • Grafts were stable after long-term storage at 4 °C.
    • In vivo studies showed excellent patency, resisting dilatation, calcification, and intimal hyperplasia.

    Conclusions:

    • Tissue-engineered vascular grafts are a viable alternative for patients unsuitable for traditional grafts.
    • These grafts demonstrate promising preclinical results for hemodialysis and arterial bypass applications.
    • Readily available, non-immunogenic engineered grafts could address limitations in current vascular reconstruction.